An avid meditator and accomplished dancer and actress, Dewan made her Acting debut on the Fox Sitcom television series Quintuplets. Dewan has since guest appeared on shows such as The Playboy Club, The Young and the Restless, Joey and Melrose Place.
In 2005 Dewan portrayed the role of the protagonist in the independent Supernatural Horror film Tamara. Dewan starred as the female lead in the Dance Drama film Step Up as Nora Clark a dance student who is partnered with a troubled Tyler Gage who is sent to spend his community service as a janitor at the school. The film opened to widespread success and went on to make $119 million worldwide. The role is widely considered Dewan’s breakout role.
In August 2010, Dewan was cast in the ensemble Crime Heist film Setup, starring alongside 50 Cent, Bruce Willis and Ryan Phillippe.
In March 2011 Dewan was cast as a series regular in the NBC pilot The Playboy Club with Laura Benanti. Dewan portrayed the role of Bunny Janie a very provocative playboy bunny who works at a Playboy Club in Chicago during 1961.
Last year, Dewan shot the romantic-comedy film 10 Years, produced by husband Channing Tatum, and was released on September 14, 2012 after premiering at the Toronto Film Fest.
Along with friends Reid Carolin, Adam Martingano, Brett Rodriguez and husband Channing Tatum, Dewan started a production company called 33andOut Productions. Their first production is a documentary called Earth Made of Glass that follows the Rwandan President Paul Kagame. The film was selected to premiere at the 2010 Tribeca Film Festival.